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The 'Frances Ha' director's latest merges the cynicism and sunniness he so often veers between.

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“Y’know, back then, I was the headliner,” Harold Meyerowitz (Dustin Hoffman) insists, to no one in particular. His old pal R.J. (Judd Hirsch) is the subject of a big retrospective show at the Museum of Modern Art, and Harold is feeling as though his work – and that’s how it’s always referenced, by himself and his family, “the work” – isn’t being properly appreciated. He isn’t getting a MoMA retrospective; hell, the college where he taught for decades is only offering him prominent placement in a faculty showcase. “Group show, no,” he announces. “That’s essentially an insult!”

One of the most painful yet undeniable truths captured by The Meyerowitz Stories (New and Selected) , the new film by Noah Baumbach, is the specific experience of being an also-ran, an almost-famous, how that breeds a particular kind of personal and professional resentment, resulting in both a general unpleasantness and an overall dislike for pretty much everything that anyone else creates. We met a father like that in Baumbach’s quietly masterful Prada Pointed BowAccented Pumps Clearance 1nN4TPO
, and Harold Meyerowitz shares some of that characters qualities (most notably, casual, unprompted critiques like “I find Maugham to be skillful without being an artist”). But if Baumbach is returning to that film’s preoccupations, he’s also approaching them from a more mature perspective, suggesting a way to get past the kind of paralyzing anger our bad parents can create. The new film about getting older, about coming to terms with who these people are, and figuring out how to be your own person anyway.

As suggested by the title, Baumbach breaks his narrative into a series of short stories, some of them focused on individual members of this extended, dysfunctional family. There is Danny (Adam Sandler), whom we first meet as he’s trying to find a parking spot in Manhattan, which is about as savvy an example of “characterization through action” as I can imagine; he’s a man in transition, sending his daughter Eliza (Grace Van Patten) off to college, an event that he and his wife were waiting for before ending their marriage. So he has both empty nest and newly single syndromes happening, a fusion that doesn’t exactly create a personality of confidence and strength.

His sister Jean (Elizabeth Marvel) first appears with the line “I made cookies, but I stepped in dog shit,” and rarely has an introduction been more apt. She’s a wallflower, though as we find out more about her, it seems not entirely by her choosing. “You guys will never understand what it’s like to be me in this family,” she says late in the film, and by the point she says it, we nod in agreement, like family members ourselves.

Their half-brother Matthew (Ben Stiller) was always his father’s favorite, not just to Danny’s chagrin, but Matthew’s: “I got your focus,” he tells Harold, “which fucked me up in a whole other way.” In sharp contrast to his half-brother, Matthew is perceived as a success: he’s wealthy, has his own business, works with celebrities, has a wife and small child, and (most importantly) lives far, far away, in Los Angeles. He only makes it into town occasionally, and only for business; in perhaps the film’s finest and funniest extended sequence, he tries to squeeze in a quick lunch with his father, and it turns into a series of perceived slights, mild irritations, and changing locations. The son is chagrined. The father is oblivious.

Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis

This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-α mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-α mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis. PMID:17047296

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Bi, Lianxiang; Rahaman, Mohamed N; Day, Delbert E; Brown, Zackary; Samujh, Christopher; Liu, Xin; Mohammadkhah, Ali; Dusevich, Vladimir; Eick, J David; Bonewald, Lynda F

2013-08-01

Borate bioactive glasses are biocompatible and enhance new bone formation, but the effect of their microstructure on bone regeneration has received little attention. In this study scaffolds of borate bioactive glass (1393B3) with three different microstructures (trabecular, fibrous, and oriented) were compared for their capacity to regenerate bone in a rat calvarial defect model. 12weeks post-implantation the amount of new bone, mineralization, and blood vessel area in the scaffolds were evaluated using histomorphometric analysis and scanning electron microscopy. The amount of new bone formed was 33%, 23%, and 15%, respectively, of the total defect area for the trabecular, oriented, and fibrous microstructures. In comparison, the percent new bone formed in implants composed of silicate 45S5 bioactive glass particles (250-300μm) was 19%. Doping the borate glass with copper (0.4 wt.% CuO) had little effect on bone regeneration in the trabecular and oriented scaffolds, but significantly enhanced bone regeneration in the fibrous scaffolds (from 15 to 33%). The scaffolds were completely converted to hydroxyapatite within the 12week implantation. The amount of hydroxyapatite formed, 22%, 35%, and 48%, respectively, for the trabecular, oriented, and fibrous scaffolds, increased with increasing volume fraction of glass in the as-fabricated scaffold. Blood vessels infiltrated into all the scaffolds, but the trabecular scaffolds had a higher average blood vessel area compared with the oriented and fibrous scaffolds. While all three scaffold microstructures were effective in supporting bone regeneration , the trabecular scaffolds supported more bone formation and may be more promising in bone repair. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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